TNFSF4 and melanoma: In comparison, intratumorally injected LNPs delivering OX40L mRNA in combination with IL‐23 and IL‐36γ mRNA in the same melanoma model resulted in only 40% of the mice being alive after 35 days, despite excellent delivery of the mRNA.[54] Importantly, these LNPs were formulated at a dose of 1.67 μg OX40L mRNA per injection,[54] which is more than 4 orders of magnitude higher than the amount of Ox40L mRNA (58 pg per injection, corresponding to 2 ng per kg bodyweight) delivered by EVs produced with our technology.