TWIST1 and breast neoplasm: Also, recent studies have indicated that mechanotransduction can happen independently of YAP in MCF10A cells cultured in alginate‐based 3D models, as well as in human breast tumor samples, suggesting a context‐dependent role for YAP.[16] Other studies showed that matrix stiffness can drive EMT in a YAP‐independent manner, namely via TWIST1‐regulated mechanotransduction pathways.[58] Our observation of TWIST1 upregulation in stiff versus soft hybrid hydrogels supports this possibility.