The most upregulated proteins include AEBP1, BGN, COL11A1, ELN, and LAMA5, which have all been identified in breast tumors.[32, 35, 36, 37, 38] The most downregulated proteins include SERPINB12, TGM3 and FGL2, which have been associated with tumor suppression.[39, 40, 41]. This evidence concerns the gene BGN and breast neoplasm.