Regarding the processes of cardiac remodelling and the state of tissue fibrosis, we found that gene expression of fibronectin 1 and collagen (type I and III) were elevated five weeks after the last DOXO injection (not significant after two weeks), but galectin 3 was elevated already at the very early phase of HF development (week +2; Fig. 9A–D). This evidence concerns the gene LGALS3 and hydrops fetalis.