This study aims to understand the tracer metabolism and physiological distribution of [18F]AlF-PSMA-11 via a head-to-head comparison with [68Ga]Ga-PSMA-11 PET, as well as to investigate the application of [18F]AlF-PSMA-11 PET in diagnosing PCa, especially the added value of dual-phase imaging in PCa management. This evidence concerns the gene FOLH1 and posterior cortical atrophy.