Previous studies have demonstrated that the oocyte‐specific depletion of the catalytic subunits of CTCF‐binding partners SWI/SNF complex, SMARCA453 and SMARCA5,23 results in female subfertility or infertility, manifesting as defects in oocyte meiosis and subsequent embryonic development arrest. The gene discussed is CTCF; the disease is female infertility.