The primary complication of SARS-CoV-2 infection, Acute Respiratory Distress Syndrome (ARDS), stems from a ‘cytokine storm’ triggered by the uncontrolled release of proinflammatory cytokines and chemokines from immune cells, including IL-6, TNF-α, IFN-γ, and others. The gene discussed is TNF; the disease is acute respiratory distress syndrome.