GPX4 and metabolic dysfunction-associated steatotic liver disease: In addition, in the antioxidant signaling pathway Keap1/NRF2/ARE, Gao et al. found that a substance called dehydroabietic acid binds to Keap1, activates NRF2-ARE, induces downstream gene expression, which in turn upregulates GSH, GPX4, inhibits ROS accumulation and lipid peroxidation, suppresses ferroptosis and NAFLD [148].