GSDMD and metabolic dysfunction-associated steatohepatitis: The deficiency of caspase-11 significantly reduced liver injury and inflammation in mice, downregulated the activation of GSDMD and IL-1β, and the expression of fibrillation-related factors (TGF-β, α-SMA, and alpha-1 type I collagen) was also reduced, revealing a critical role for caspase-11 in NASH [95].