GSDMD and steatosis: In studies of non-canonical signaling pathways, it has been found that Jiangzhi Ligan Decoction (JZLGD) ameliorated steatosis, inflammation, and pyroptosis in HFD-fed rats not only by inhibiting the NLRP3/caspase-1/GSDMD-mediated typical pyroptosis pathway but also by decreasing the levels of LPS in the hepatic portal vein of NAFLD rats, which prevented caspase-11 and GSDMD activation, inhibited the LPS/caspase-11/GSDMD-mediated non-canonical signaling pathways, and alleviated NALFD [114].