IGFBP7 and metabolic dysfunction-associated steatotic liver disease: Similarly, Insulin-like growth factor binding protein 7 (IGFBP7) deletion in the zebrafish NAFLD model significantly increased the expression of the nuclear receptor coactivator 4 (NCOA4), increased NCOA4-mediated ferritin autophagy (ferritinophagy), maintained intracellular iron homeostasis, and reduced the occurrence of hepatocyte ferroptosis [140].