In exploring obstructive sleep apnea hypopnea syndrome (OSAHS)-associated NAFLD, researchers found that intermittent hypoxia (IH) increased RIPK3 upregulation caused by PA treatment of LO2 cells, promoted RIPK3-dependent necroptosis, and increases hepatic oxidative stress, and inflammatory responses. This evidence concerns the gene RIPK3 and metabolic dysfunction-associated steatotic liver disease.