GPX4 and metabolic dysfunction-associated steatohepatitis: Icariin, a flavonoid abundant in the herb Epimedium, ameliorated MCD diet-induced lipid peroxidation, restored mitochondrial structure in the livers of NASH mice, and exerted hepatoprotective effects through the activation of Nrf2, which in turn significantly elevated the protein levels of GPX4 and a cystine/glutamate transporter (xCT) [143].