PER2 and metabolic dysfunction-associated steatohepatitis: Shu et al. [152] found that time-restricted feeding suppressed the expression of the circadian gene Per2, and that specific knockdown of Per2 in hepatocytes promoted the expression of PPARα, thereby reducing lipid peroxidation levels, inhibiting the ferroptosis-related genes expression, improving mitochondrial morphology, and ultimately effectively mitigating NASH.