CASP1 and metabolic dysfunction-associated steatotic liver disease: Similarly, the herbal formulation Jinlida granule has been found to reduce the expression of NLRP3, caspase-1, IL-1β, and IL-18 in HFD-induced mouse livers as well as FFA-induced HepG2 cells, demonstrating its potential to alleviate liver injury and exert a protective effect against NAFLD by reducing hepatocyte pyroptosis [97].