Therefore, our results indicated the existence of tumor-reactive T cells (pTRTs and pTRT-relevant cells) in the BM of AML patients carrying the RUNX1::RUNX1T1 which showed a continuous spectrum of differentiation from the stem-like cluster to the terminally differentiated cluster (Fig. 2H, Supplementary Figure S2G). Here, RUNX1 is linked to acute myeloid leukemia.