LDLR and breast cancer: Related to this, high-cholesterol diet in BALB/c mice carrying GFP-expressing 4T1 or MDA-MB-231 breast cancer xenografts promotes intravasation of cancer cells, which can be inhibited by blocking LDL binding to LDLR [102], and human breast tumors containing higher levels of esterified cholesterol have higher LDLR expression and are more aggressive [71].