AKT1 and cholangiocarcinoma: At the histological level, AKT/YAP and AKT/TAZ tumors consisted almost exclusively of pure cholangiocarcinoma lesions, although scattered lipid-rich hepatocellular preneoplastic lesions could be detected in the two rodent cohorts, with a predominance in AKT/YAP livers (Figs. 5C and 6C, upper panels, and Supplementary Figures 3A and 4A).