In another study, Peng et al. (2012) evaluated the impact of eight polymorphisms, including TNF-α, IL-6, IL-1β, COX-2, and IL-10, on lung cancer risk across six studies (728 cases and 904 controls), showing that variants like TNF-α 308G > A did not significantly influence lung cancer susceptibility [41]. This evidence concerns the gene IL6 and lung cancer.