Several studies have demonstrated that MANF expression is increased in various pathological conditions associated with ER stress, including multiple myeloma, glomerular disease, rheumatoid arthritis, hepatic damage and systemic lupus erythematosus (Tousson-Abouelazm et al. 2020; Dernoncourt et al. 2021). The gene discussed is MANF; the disease is rheumatoid arthritis.