APC and colorectal carcinoma: To determine whether loss of Dock2 promotes inflammation-associated CRC development we crossed mice carrying a whole mouse ‘deletion first’ Dock2tm1a allele to a well characterised villin-creERT2Apcfl/+ intestinal CRC model [17] (Fig. S1A, B) generating cohorts of control villin-creERT2Apcfl/+ (Vil Apc) and experimental villin-creERT2Apcfl/+Dock2tm1a/tm1a (Vil Apc Dock2) mice.