STING1 and neoplasm: The DNA methylation level of the promoter region of TMEM173 (STING) was significantly and inversely correlated with mRNA expression of TMEM173 (STING) in GC (Fig. 3F), suggesting that the lower frequency of the DNA methylation might contribute to the higher expression of tumor cell-intrinsic STING in dMMR GC, but not in EBV (+) GC.