TARDBP and Alzheimer disease: The presence of aggregated TDP-43 proteins has been observed within the cytoplasmic inclusions of neurons affected by various neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer’s disease (AD), and Parkinson’s disease (PD) (Arseni et al, 2022; Josephs et al, 2014; Ling et al, 2013; Taylor et al, 2016).