Our results indicated that combinations of various SNPs at rs1799883 (FABP2) and rs3813865 (CYP2E1), rs1042522 (TP53), and rs2279744 (MDM2), as well as genotype combinations at rs3813865 (CYP2E1) and rs1042522 (TP53), were associated with a higher incidence of CRC. Here, CYP2E1 is linked to colorectal carcinoma.