Given this gap in knowledge, the present study was undertaken to investigate the association of genotypes at rs1799883 in FABP2, rs3813865 in CYP2E1, rs1042522 in TP53, and rs2279744 in MDM2, both individually and in various combinations, with the development of CRC in subjects enrolled from Punjab, Pakistan. Here, CYP2E1 is linked to colorectal carcinoma.