Furthermore, upon rechallenging mice with intravenous injections of MC38-OVA tumor cells, a notable increase in the expansion of transferred CD8 T cells was observed in the blood in the group that received adoptive cell therapy (ACT) of PHD2/3 KO OT-1 T cells compared to the control group (Suppl Fig. 3D). The gene discussed is CD8A; the disease is neoplasm.