CD8A and neoplasm: To decipher mechanisms behind the enhanced anti-tumor efficacy of TCRP1A CD8 T cells knocked out for PHD2/3 or cultured under hypoxia, we analyzed and compared the transcriptome of activated TCRP1A CD8 T cells with HIF-1α KO or PHD2/3 KO exposed to different oxygen conditions (21% O2 or 1% O2) for 48 h (Fig. 7a–c).