Circadian rhythms can be modulated by various therapeutic strategies including re-synchronizing the clock, modulating the output, or fine-tuning the central SCN clock.35 Recent research has demonstrated that circadian rhythms in the expression of anti-tumor immune components can be therapeutically exploited,36 indicating that regulation of the circadian clock may be a viable therapeutic strategy, particularly for diseases associated with disruption of circadian rhythms.35 This might be a hint of potential clinical applications of similar therapeutic strategies in other disease models. Here, CLOCK is linked to neoplasm.