However, antibodies against high prevalence antigens can also cause severe HDFN, as in the case report described by Levitt et al.4The administration of prophylactic anti-D immunoglobulin in RhD negative women after delivery of a RhD positive child significantly reduced the incidence of HDFN related to anti-D in high-income countries after the 1960s.1 Here, RHD is linked to fetal erythroblastosis.