Its lncRNA gene product downregulates the production of inflammatory chemokines by keratinocytes during wound healing [88], is itself downregulated in the lesional skin of psoriasis patients [88,90], and was shown to regulate a range of immune-related genes in invasive breast cancer, including the interleukin receptor subunit gene IL27RA and the immunoglobulin A and D constant region heavy chain genes IGHA1 and IGHD [89]. Here, IGHD is linked to invasive breast carcinoma.