miR-615-3p plays a multifaceted role in cancer, promoting proliferation, migration, and inhibiting apoptosis in gastric cancer, enhancing adverse outcomes in prostate cancer, facilitating the epithelial-mesenchymal transition and metastasis in breast cancer, and participating in the repression of hTERT and tumorigenesis in collaboration with HoxC5, while also promoting hypoxia-induced glycolysis in non-small cell lung cancer through interaction with HMGB3 [101–104]. The gene discussed is HMGB3; the disease is gastric cancer.