SMAD2 and polyostotic fibrous dysplasia: Compared with the model group, Gen100 significantly reduced the relative expression of TGF-β1 and Smad2/3 in lung tissue (P<0.01) and was comparable to the PFD group (P>0.05) [FB(6,24) = 6.967, p = 0.000], [FC(6,29) = 8.178,p = 0.000] (Fig 6).