Moreover, a meta-analysis of 12 longitudinal and 2 cross-sectional studies, including a group of 300 children/adolescents and 137 adults, showed that subjects with CAH have higher values of HOMA-IR, although no differences were observed for fasting insulin, fasting glucose, as well as for glucose and insulin levels 2 hours after oral glucose load (179). Here, INS is linked to congenital adrenal hyperplasia.