HOMA-IR and HbA1c higher, insulin sensitivity index (ISI) lower vs controls; more insulin-resistant subjects with CAH than in controls; higher values of first phase insulin and total insulin, lower values of disposition index based on first phase and total (clamp 180 minutes) insulin secretory rate vs control subjects; reduced hepatic insulin clearance in subjects with CAH than in controls. The gene discussed is INS; the disease is congenital adrenal hyperplasia.