Seventeen of the TFs with motifs impacted by type 2 diabetes variants are predicted effector transcripts in at least one cell type (HES2, ZNF384, STAT6, NR2C1, ONECUT1, TCF12, SOX15, TP53, HNF1B, TCF4, TCF3, OSR1, PPARG, NFKB1, CREB3, ZBTB6, ZBTB26). Here, CREB3 is linked to type 2 diabetes mellitus.