Among 221 eQTL-linked genes associated with type 2 diabetes risk loci in pancreatic/islet tissues, only 12 had open proxies in chromatin contact with their promoters in EndoC-BH1 cells: SMCO4, DOC2A, OPRL1, TUFM, YBEY, MTMR11, UBE2D3, PLEKHA1, GPSM1, RNF6, ABCD9 and AGFG2. Six genes were implicated by both liver eQTLs and our promoter-focused Capture-C in HepG2 cells, while 25 genes were linked to adipose tissue eQTLs and our Capture-C in at least one adipose model (SGBS_undiff, SGBS_diff) (ESM Table 11). Here, OPRL1 is linked to type 2 diabetes mellitus.