Additionally, we compared our findings with a recent CRISPR interference (CRISPRi) screen identifying potential type 2 diabetes effectors, noting eight overlapping genes, seven associated with decreased insulin content and one with increased content (decreased: CHD4, PRPF18, GMEB1, CREB3, PITPNM2, SIN3A and ATP6 V1C1; increased: FADS1). This evidence concerns the gene CREB3 and type 2 diabetes mellitus.