Seventeen of the TFs with motifs impacted by type 2 diabetes variants are predicted effector transcripts in at least one cell type (HES2, ZNF384, STAT6, NR2C1, ONECUT1, TCF12, SOX15, TP53, HNF1B, TCF4, TCF3, OSR1, PPARG, NFKB1, CREB3, ZBTB6, ZBTB26). The gene discussed is HES2; the disease is type 2 diabetes mellitus.