We and others have demonstrated that IL-1β and IL-18 are elevated in the plasma of patients with severe COVID-19 (7, 10, 17), and lung sections from autopsies of patients who died of COVID-19 contain increased NLRP3 specks (11, 15), consistent with inflammasome activation during SARS-CoV-2 infection. Here, IL18 is linked to COVID-19.