For example, in a retrospective genomic analysis using The Cancer Genome Atlas Program database, male melanoma patients harbored more TP53 gene mutations than female melanoma patients (TP53 mutation frequency per 100,000 people for males vs. females: 4.7 vs. 2.2; p ≈ 0), which was associated with poorer prognosis.30 This evidence concerns the gene TP53 and melanoma.