SREBF2 and neoplasm: Consistent with our cultured cell experiments (Fig. 7B), SREBF1/2 double KO xenografts phenocopied SCAP KO xenografts and failed to grow in nude mice, indicating that the presence of either SREBP1 or SREBP2 activity is sufficient to support Pa03c xenograft growth and suggesting that inhibition of both transcription factors is required to prevent PDAC tumor growth.