This study found increased plasma levels of proinflammatory cytokines: TNF‐α, IFN‐ɣ, IL‐1β, IL‐6, and GM‐CSF, and the anti‐inflammatory cytokine IL‐10 in malaria‐infected children than the controls without malaria, and the levels were higher in participants with high parasitemia. This evidence concerns the gene CSF2 and malaria.