The intense sequestration exacerbates the inflammatory response and cause cytokine storm, especially increasing IL‐10, GM‐CSF, IL‐6, IL‐1β, IFN‐ɣ, and TNF‐α levels, which promotes the progression of severe malaria.4, 8, 10, 26, 27, 28, 29. This evidence concerns the gene TNF and malaria.