Children with high parasite density (>10,000 parasites/μL) had higher plasma levels of TNF‐α (p < .001), IFN‐ɣ (p < .001), IL‐1β (p < .001), IL‐6 (p < .001), GM‐CSF (p < .001), and IL‐10 (p < .001) than those with low parasitemia. This evidence concerns the gene CSF2 and parasitic infectious disease.