NUC could exert anti‐obesity effects through multiple pathways and targets, such as inhibition of lipogenesis via activating AMPK signalling pathway (Ma et al., 2015) and regulating Akt‐mTORC1 signalling pathway (Yoo et al., 2019) and decrease of intracellular lipid accumulation by modulating the expression of lipogenic genes and adipokines (Xu et al., 2021). Here, NUCB1 is linked to obesity due to melanocortin 4 receptor deficiency.