MDM2 and Myocardial fibrosis: Heart rate, the ST-segment amplitude, and the Q-wave ↓; EF and FS ↑; LVIDs and LVESV ↓; LVDP, LVEDP, -dp/dt max and T ↓; +dp/dt max and V max ↑; AST, LDH, CK-MB, and α-HBDH ↓; myocardial injury and myocardial fibrosis ↓; type 1 and 2 collagen ↓; Bax and cleaved caspase-3 expression ↓; Bcl-2 expression ↑; AT1R, Ankrd1, and P-p53 (ser15) levels ↓; Mdm2 level ↑