AKT1 and cancer: Another isoquinoline alkaloid, CHLD, has also shown effectiveness in triggering apoptosis in HeLa cells, exerting anti-cancer effects by upregulating the expression of pro-apoptotic genes such as, p38 and p53 and downregulating the expression of anti-apoptotic genes including AKT, PI3K, JAK3, STAT3, E6, and E7 (Paul et al., 2012).