TP53 and familial pancreatic carcinoma: Moreover, CHLD induces G2/M phase block in BxPC-3 and MIA PaCa-2 cells by downregulating CDK 1, and increases S-phase block induced by GADD 45a by upregulating p21 and p53, culminating in pancreatic cancer cell apoptosis through Caspase-3 cleavage (Jang et al., 2021).