ATF4 and glioblastoma: In 2023, by using Western blot and flow cytometry, Charlotte Linke et al. (Linke et al., 2023) found Mit A in combination with ADI therapy upregulates ATF4 and cyto c, promoting apoptosis in GBM cells, and synchronized is superior to sequential administration, illustrating the great potential of this organic combination of therapies based on metabolic defects and cell killing SOD is an antioxidant enzyme whose primary function is to neutralize harmful superoxide radicals produced during cellular metabolism and is a stress-associated protein (Tyagi and Shumayla Singh, 2019).