Resveratrol, a flavonoid with unique pharmacological activities, can reduce the proliferation of GBM stem cells (GSCs) by decreasing the activation of ERK, the expression of VEGF, EGF, and the markers of stemness (e.g., CD133, OCT4, and Nestin), while activating MAPK phosphatase-1 (MKP-1), thereby inhibiting cell proliferation. The gene discussed is POU5F1; the disease is glioblastoma.