Eleanor Bishop et al. (Bishop et al., 2022) identified arginine-assisted trophic features in pediatric high-grade and low-grade gliomas, ventricular meningiomas, and medullo-blastomas, with a high percentage of tumors in pHGG samples deficient in OTC, ASS1, and ASL, suggesting potential sensitivity to arginine depletion therapy. This evidence concerns the gene OTC and central nervous system cancer.