TSHR and eye disorder: It is believed that the level of thyrotropin receptor antibody (TRAb) in GD patients is increasing, and it will produce pro-inflammatory factors and glycosaminoglycans after combining with thyrotropin receptor (TSHR) in adipocytes and fibroblasts, leading to diplopia, exophthalmos, conjunctival congestion, and even blindness (Bahn, 2015).