Other glial cell studies reported a significant loss of hippocampal microglia,92 elevated reactivity of astrocytes and microglia in cortex and hippocampus of rabbits,66 dogs,31,65 and rodents,20,22,36,37,39,41,44,49,50,52–54,93–95 an increase in CD68+96 or EDI+37 (markers for mainly activated microglia/macrophages97,98) cells in rats, and a decreased glial cell viability and ability to restrict tumor cell progression.77 In contrast, a few studies showed neither damage to normal astrocytes30 nor gliosis.21,95. Here, CD68 is linked to neoplasm.