PDX1 and familial pancreatic carcinoma: IPF1/PDX1 regulates downstream molecules such as Neurogenin 3 (NGN3), Forkhead Box A2 (FOXA2), Hepatocyte Nuclear Factor 1 Beta (HNF1B), Fibroblast Growth Factor Receptor 2 (FGFR2IIIB), and Spondin 1, which are involved in pancreatic development, differentiation, and function in pancreatic cancer (Svensson et al., 2007; Oliver-Krasinski et al., 2009).