SMO and neoplasm: Natural compounds like epigallocatechin-3-gallate and sulforaphane inhibit pancreatic CSCs via Hh signaling suppression. Smo inhibitors (e.g., GDC-0449, IPI-926, LDE225) and Gli transcription factor inhibitors (e.g., GANT-61) target Hh signaling for anti-tumor effects; (Quatannens et al., 2022; Onishi et al., 2022; Nguyen and Cho, 2022; Huang et al., 2013)