KRAS and familial pancreatic carcinoma: In pancreatic cancer, NF-κB is actively expressed due to oncogenic Kras mutations and inflammatory signaling pathways. NF-κB activation in PDAC is influenced by chemokines, cytokines, and chronic inflammation and it controls molecules related to angiogenesis and metastasis. (Prabhu et al., 2014; Silke and O’Reilly, 2021)