In metastatic colorectal cancer, the integrin α2β1 signal interacts with Cadherin-17 (CDH17), promoting activation of ITGB1 and recruitment of Talin, thereby facilitating proliferation and metastasis of metastatic colorectal cancer (Bartolomé et al., 2014). The gene discussed is ITGB1; the disease is metastatic colorectal cancer.