The activation of IGF1Rβ associated with the HSPA1L/ITGAV complex enhances the tumor stemness and radiotherapy resistance of non-small cell lung cancer through downstream AKT/NF-κB or AKT/GSK3β/β-catenin activation pathways (Choi et al., 2020). Here, AKT1 is linked to non-small cell lung carcinoma.