Under stress conditions, upregulation of the G protein-coupled receptor lysophosphatidic acid receptor 4 (LPAR4) drives stress tolerance in breast cancer stem cells (CSCs) and promotes the initiation of cancer stem cells and tumors by activating downstream fibronectin-binding integrins α5β1 and αvβ3 (Wu, Weis, and Cheresh, 2023). The gene discussed is LPAR4; the disease is cancer.