ITGA6 and glioblastoma: Researchers have identified three subgroups of stem cells in glioblastoma stem cells: mesenchymal (MES), proneural (PN), and classical (CL) (Wang Q. et al., 2017), with ITGA6 maintaining the stemness of PN-GSCs but enhancing the radiotherapy resistance of MES-GSCs(Stanzani et al., 2021).