Studies show that ITGB1 is used to enrich endometrial cancer stem cells, and EXOSC5 regulates the signaling of ITGB1 through the NTN4/ITGB1 axis, enhancing the cancer stemness of endometrial cancer stem cells (Y.H. Huang et al., 2024). The gene discussed is ITGB1; the disease is endometrial cancer.