Research has shown that ITGAV can interact with CSPG4, regulating the microenvironment of Glioma Initiating Cells (GICs) by upregulating Integrin-ERK/MAPK signaling, thereby promoting the maintenance and differentiation of GICs and leading to tumor formation (Niibori-Nambu et al., 2024). Here, ITGAV is linked to neoplasm.