Cytokine receptor interactions regulate immune responses and inflammatory processes23, while ECM receptor interactions play a key role in tumor growth and metastasis24, and finally, p53 is an important tumor suppressor gene25, which suggests that dysfunction of p53 may be present in the high-risk group, and that the above results may be associated with a poorer prognosis in the high-risk group. This evidence concerns the gene TP53 and neoplasm.