To further explore the underlying mechanisms by which MMP11 promoted the migration and invasion of CRC, bioinformatics analysis was conducted, which revealed that differential MMP11 expression was correlated with the “PI3K-AKT signaling pathway,” the “TGF-β signaling pathway,” and the “Wnt signaling pathway.” The results demonstrated that MMP11 knockdown reduced the expression of Slug but did not affect the expression of Vimentin, E-cadherin, N-cadherin, or Snail. This evidence concerns the gene CDH2 and colorectal carcinoma.