Furthermore, Robo4 siRNA reversed the up-regulation of S-100β and NSE levels, prevented brain injury, facilitated apoptosis, and decreased MAP2 levels in the frontal cortex and hippocampus of CCH rats injected with BMP-PEI-Slit2/BMMNCs (Figures 5C-F). This evidence concerns the gene ROBO4 and columnar cell hyperplasia of the breast.