KDM2A and pachyonychia congenita: Our findings revealed significantly upregulated expression levels (p < 0.5) of KDM1A, KDM1B, KDM2A, KDM2B, KDM3B, KDM4A, KDM5A, KDM5B, and KDM6B in PC tissue, suggesting their potential oncogenic role (Fig. 2).