Therefore, we investigated the effects of SGLT2 inhibitors on various clinical outcomes, including acute kidney injury (AKI), acute kidney disease (AKD), ESRD with dialysis, congestive heart failure (CHF), acute pulmonary embolisms (APEs), cardiac arrhythmias, acute myocardial infarction (AMI), sepsis, and GUTIs, in patients with stage 3~5 disease. Here, SLC5A2 is linked to Sepsis.