FAP and hepatocellular carcinoma: First, the proportion of different fibroblast subtypes in the HCC samples was evaluated, and FAP+ CAF subtype exhibited the highest cell percentage compared to other subtypes (HCC1_T: 30.05%, HCC2_T: 28.61%, HCC3_T: 20.54%, HCC4_T: 25.38%) (Figure 3A).