To gain further insight into the pivotal role of fibroblasts in shaping the microenvironment of liver cancer, we referenced previously reported fibroblast subtype-specific markers and categorized them into eight clusters (Fb_01_ADIRF, Fb_02_APOC1, Fb_03_FAP, Fb_04_HLA-DRB1, Fb_05_PLVAP, Fb_06_TOP2A, Fb_07_CFD, Fb_08_GPM6B) 24 (Figure 1D, Figure S1D & S1E, Table S3). In comparison to AL, Fb_03_FAP was observed to be elevated in all liver cancer types, representing about 50% of all fibroblasts (Figure 1E, Figure S1F). This evidence concerns the gene HLA-DRB1 and liver cancer.