Additionally, Fb_08 was enriched to nerve-related pathway with high expression of S100B and GPM6B, which belonged to fibroblast-like peripheral nerve cells, which was also found in Luo et al.'s study, but this type of cells was mainly enriched in colorectal cancer and suggests the impact of perineural invasion on patient risk 24. The gene discussed is GPM6B; the disease is colorectal cancer.