COL1A1 and neoplasm: Several scRNA-seq studies have identified different pan-cancerous CAF subtypes 24, 49, 84, 85, highlighting the importance of matrix-associated CAFs in tumor promotion, characterized by high expression of COL1A1, FAP, and POSTN. These studies are of great significance in resolving the heterogeneity of CAFs and promoting the development of CAF-targeted drugs.