In contrast to the translational regulatory role of YTHDF3, Y-box binding protein 2 (YBX2) forms stable cytoplasmic condensates through recruiting YTHDF2 and promotes the degradation of m6A-modified HSPA6 mRNA in endometrial adenocarcinoma-derived Ishikawa cells. The gene discussed is YBX2; the disease is endometrium adenocarcinoma.