Notably, other than cancer and central nervous system diseases, the range of diseases that might be treated with sonogenetics may be wide, including orthopedic disorders, anaphylaxis, metabolic disease, tissue engineering and regenerative medicine, and others 119-122, for example, this technology may be soon used to activate heart cells and insulin pumps: implanting SSMs in the human heart/pancreas and activating these cells with an external US device could revolutionize pacemakers and diabetes treatment. The gene discussed is INS; the disease is metabolic disease.