Representative high-resolution images of the tumor margin and the tumor core (Figure 6A) and CD4+ cell quantification (Figure 6B) revealed about 7-fold increased infiltration of CD3+CD4+ T cells into the TME of responsive MC38 tumors, whereas no CD3+CD4+ T cells could be identified in nonresponsive MC38 tumors or tumors from sham-treated mice (Figure 6A, B). This evidence concerns the gene CD4 and neoplasm.