Due to the known association between dietary iron deficiency, learning and memory, and hippocampal function (Weinberg et al., 1979; McEchron et al., 2005; Ennis et al., 2019; McCann et al., 2020; Porras and Rouault, 2022), we hypothesized that disruption of iron metabolism regulation by ablation of Irp2 could impair long-term learning and memory in a similar manner. Here, IREB2 is linked to Iron deficiency anemia.