NFKB1 and type 2 diabetes mellitus: Due to these reasons, the present study sought to study the effect of combined administration of Brazil nut and metformin on oxidative stress, apoptosis, and the MAPK-mTOR/NFkB/interleukin 10 (IL-10) signaling pathways in the heart of fructose/streptozotocin (STZ)-induced type 2 diabetic rats, and to analyze the bioactive compounds in 50% aqueous ethanol extract of the Brazil nut using Gas Chromatography Mass Spectrophotometry (GCMS) and Fourier Transform Infrared Spectroscopy (FTIR).