PTGS2 and ischemia: Previous studies reported that exposure of rats to a low dose (75 mg) of Brazil nut resulted to their protective action against renal inflammation and apoptosis in a rat model of ischemia and reperfusion injury, whereas exposure of rats to 150 mg of Brazil nut exacerbated the renal expression of cyclooxygenase-2 in rats with ischemia and reperfusion injury (84).