TNC, COL18A1 and COL12A1 gene expression characterize fibroblasts known as ECM-CAF (Extracellular Matrix-Cancer Associated Fibroblasts) which participates in the aberrant remodeling of the extracellular matrix in breast cancer (Papanicolaou et al., 2022; Minini and Fouassier, 2023). The gene discussed is COL12A1; the disease is cancer.