To summarize, using various bioinformatics methods, this study discusses the possible mechanisms of occurrence and development of psoriasis from different perspectives along with deep data mining to identify the key gene, namely IFIT3. Our research not only uncovers the pivotal roles of the IFIT3 gene in the immune and signal transduction pathways but also identifies its principal associated pathways in psoriasis through GSEA. This evidence concerns the gene IFIT3 and psoriasis.