We conduct this meta-analysis, which showed that TACE/HAIC TP is better than TP for uHCC, and we speculate the mechanism of synergistic anti-tumor effects of triple treatments may be as follows: (1) TKI mainly inhibits activities of vascular endothelial growth factor receptors (VEGFR1-3) and fibroblast and growth factor receptors (FGFR1-4), which the inhibition of VEGFR and FGFR can elicit antitumor immunity and enhance PD-1 checkpoint blockade in HCC (40). Here, KDR is linked to hepatocellular carcinoma.